My experience: sandwhich in my carry-on along with a frozen ice pack, the reusable white bag which comes in a foam box containing drugs. After going through the TSA inspection (xray only), I thought the TSA slipped up. However, since it had not reverted to its unfrozen liquid (jell?) state (mostly), there had been no mistake which I believe I confirmed later on the TSA web site My belief is you will not have a problem. Since your box is only ten pounds, I'd suggest you carry it on for several reasons.
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